Bone Reloaded

Biomechanical regulation of bone remodeling

About the Project

Osteoporosis affects more than 200 million people worldwide and results from an imbalance in bone remodeling. The Bone Reloaded project investigates how biomechanical signals regulate the coupling between bone resorption and bone formation.

Using a novel reversible stress-shielding model in sheep combined with spatial omics, biomechanical modeling, and computational systems biology, we aim to uncover the molecular pathways controlling bone remodeling.

Latest News

We are currently hiring

Reinhold Erben’s Lab

Postdoctoral Position

A 3-year postdoctoral position starting June 2026 at the Ludwig Boltzmann Institute of Osteology in Vienna, focusing on bone remodeling and spatial biology.

Location: Vienna + Davos collaboration

Start: June 2026

Deadline: April 20, 2026

Apply: Click anywhere on this card to apply ↗

Research includes sheep models, CT/µCT imaging, histology, spatial transcriptomics, and spatial metabolomics.

Work in a highly interdisciplinary and international environment.

Reinhold Erben’s Lab

Technical Assistant (50%)

A 3-year half-time position (20h/week) starting June 2026, supporting histology workflows and spatial biology experiments.

Location: Vienna

Start: June 2026

Deadline: April 20, 2026

Apply: Click anywhere on this card to apply ↗

Tasks include paraffin, plastic and cryo-histology, immunohistology, molecular biology, and spatial omics methods.

Ideal for candidates interested in combining lab techniques with modern multi-omics approaches.

Principal Investigators

Reinhold G. Erben

Ludwig Boltzmann Institute of Osteology, Vienna

Axel K. Walch

Helmholtz Center Munich

Jan Baumbach

University of Hamburg

Philippe Zysset

University of Bern

Peter Varga

AO Research Institute Davos

Integrated Expertise

Systems Biology of
Bone Remodeling

Bone Biology

Reinhold Erben

Biomechanics

Philippe Zysset

Implant Models

Peter Varga

Spatial Metabolomics

Axel Walch

Computational Systems Biomedicine

Jan Baumbach

DFG FWF SNF

Grant IDs

DFG: 570483888

FWF: 10.55776/PIN2327125 ↗

SNSF: 310030E_238213